Approach on the molecular mechanism of initiation, progression, and histological typing of gastric cancer from the view of gut differentiation

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790355
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: YAMAMICHI Nobutake 東京大学, 医学部附属病院, 助教 (30463897)
• Project Period (FY): 2011 – 2012
• Keywords: 胃癌 / 胃腺腫 / 胃癌組織型 / 腸上皮化生 / エピジェネティクス / 消化管分化 / cathepsin E (CTSE)

Research Abstract

We found that CTSE gene tends to express in sig/por-type gastric cancer (GC) and tend be deficient in tub1/tub2/muc-type GC cell lines. Histologic analyses of surgical specimens showed that CTSE is a marker of both gastric differentiation and sig-type GC. Analyses of endoscopically-resected gastric adenoma and tub1/tub2-type GC showed that more undifferentiated tumors with strong gastric and weak intestinal properties tend to arise from background mucosa with decreased both gastric and intestinal features. In contrast, endoscopically-resected sig-type GC tends to reflect the features of background mucosa.

Research Products

• [Journal Article] Invasion of poorly differentiated adenocarcinoma to the deep muscularis mucosae may be an indicator of lymph node metastasis in Barrett's esophageal cancer. (2013)
  • Author(s): Sakaguchi Y, Ono S, Fujishiro M, Yamamichi N, Koike K
  • Journal Title: Dig Endosc Volume: 25 Pages: 168-172
• [Journal Article] Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis. (2013)
  • Author(s): Konno-Shimizu M, Yamamichi N, Inada K, Kageyama-Yahara N, Shiogama K, Takahashi Y, Asada-Hirayama I, Yamamichi-Nishina M, Nakayama C, Ono S et al
  • Journal Title: PLoS One Volume: 8(2) Pages: e56766
• [Journal Article] Evaluation of a new image-enhanced endoscopic technology using band-limited light for detection of esophageal squamous cell carcinoma. (2013)
  • Author(s): Kodashima S, Fujishiro M, Ono S, Niimi K, Mochizuki S, Asada-Hirayama I, Konno-Shimizu M, Matsuda R, Minatsuki C, Nakayama C, Yamamichi N, et al
  • Journal Title: Dig Endosc
• [Journal Article] Factors predictive of inaccurate determination of horizontal extent of intestinal-type early gastric cancers during endoscopic submucosal dissection: A retrospective analysis (2013)
  • Author(s): Asada-Hirayama I, Kodashima S, Goto O, Yamamichi N, Ono S, Niimi K, Mochizuki S, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C et al
  • Journal Title: Dig Endosc
• [Journal Article] Narrow band imaging with magnification can pick up esophageal squamous cell carcinoma more efficiently than lugol chromoendoscopy in patients after chemoradiotherapy. (2013)
  • Author(s): Asada-Hirayama I, Kodashima S, Fujishiro M, Ono S, Niimi K, Mochizuki S, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C, Nakayama C, Yamamichi N, et al
  • Journal Title: Diagn Ther Endosc2013 Volume: 2013 Pages: 256439
• [Journal Article] Rebamipide induces dendritic cell recruitment to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-exposed rat gastric mucosa based on IL-1beta upregulation. (2012)
  • Author(s): Yamamichi N, Oka M, Inada K, Konno-Shimizu M, Kageyama-Yahara N, Tamai H, Kato J, Fujishiro M, Kodashima S, Niimi K et al
  • Journal Title: Biochem Biophys Res Commun Volume: 424(1) Pages: 124-129
• [Journal Article] Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores. (2012)
  • Author(s): Yamamichi N, Mochizuki S, Asada-Hirayama I, Mikami-Matsuda R, Shimamoto T, Konno-Shimizu M, Takahashi Y, Takeuchi C, Niimi K, Ono S et al
  • Journal Title: BMC Med Volume: 10 Pages: 45
• [Journal Article] Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis. (2012)
  • Author(s): Watanabe M, Kato J, Inoue I, Yoshimura N, Yoshida T, Mukoubayashi C, Deguchi H, Enomoto S, Ueda K, Maekita T, Yamamichi N, et al
  • Journal Title: Int J Cancer
• [Journal Article] Magnifying endoscopy with narrow-band imaging helps determine the management of gastric adenomas. (2012)
  • Author(s): Tsuji Y, Ohata K, Sekiguchi M, Ohno A, Ito T, Chiba H, Gunji T, Fukushima J, Yamamichi N, Fujishiro M et al
  • Journal Title: Gastric Cancer Volume: 15(4) Pages: 414-418
• [Journal Article] Evaluation of safetyof endoscopic biopsy without cessation of antithrombotic agents in Japan. (2012)
  • Author(s): Ono S, Fujishiro M, Kodashima S, Takahashi Y, Minatsuki C, Mikami-Matsuda R, Asada-Hirayama I, Konno-Shimizu M, Tsuji Y, Mochizuki S, Yamamichi N, et al
  • Journal Title: J Gastroenterol Volume: 47(7) Pages: 770-774
• [Journal Article] Endoscopic mucosal resection with a ligation device or endoscopic submucosal dissection for rectal carcinoid tumors: an analysis of 24 consecutive cases. (2012)
  • Author(s): Niimi K, Goto O, Fujishiro M, Kodashima S, Ono S, Mochizuki S, Asada-Hirayama I, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C, Yamamichi N, et al
  • Journal Title: Dig Endosc Volume: 24(6) Pages: 443-447
• [Journal Article] Prospective single-arm trial of two-week rabeprazole treatment for ulcer healing after gastric endoscopic submucosal dissection. (2012)
  • Author(s): Niimi K, Fujishiro M, Goto O, Kodashima S, Minatsuki C, Hirayama I, Mochizuki S, Ono S, Yamamichi N, Kakushima N et al
  • Journal Title: Dig Endosc Volume: 24(2) Pages: 110-116
• [Journal Article] Education and Imaging. Gastrointestinal: esophageal hematoma: a rare cause of upper gastrointestinal bleeding. (2012)
  • Author(s): Hirano K, Yamamichi N, Fujishiro M, Koike K
  • Journal Title: J Gastroenterol Hepatol Volume: 27(10) Pages: 1642
• [Journal Article] Discrepancy in diagnosis of gastric submucosal tumor among esophagogastroduodenoscopy, CT, and endoscopic ultrasonography: a retrospective analysis of 93 consecutive cases. (2012)
  • Author(s): Goto O, Kambe H, Niimi K, Mochizuki S, Asada-Hirayama I, Minatsuki C, Ono S, Kodashima S, Yamamichi N, Yamaji Y et al
  • Journal Title: Abdom Imaging Volume: 37(6) Pages: 1074-1078
• [Journal Article] Postprandial fullness correlates with rapid inflow of gastric content into duodenum but not with chronic gastritis. (2011)
  • Author(s): Yamamichi N, Shimamoto T, Minatsuki C, Yoshida Y, Fujishiro M, Kodashima S, Kato J, Goto O, Ono S, Niimi K et al
  • Journal Title: BMC Gastroenterol Volume: 11 Pages: 140
• [Journal Article] An effective training system for endoscopic submucosal dissection of gastric neoplasm. (2011)
  • Author(s): Tsuji Y, Ohata K, Sekiguchi M, Ito T, Chiba H, Gunji T, Yamamichi N, Fujishiro M, Matsuhashi N, Koike K
  • Journal Title: Endoscopy Volume: 43(12) Pages: 1033-1038