2012 Fiscal Year Final Research Report
Elucidation of activation mechanisms for ganglioside-deficient glial cells
| Project/Area Number |
23790361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
OHMI Yuhsuke 名古屋大学, 医学系研究科, 特任助教 (10584758)
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| Project Period (FY) |
2011 – 2012
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| Keywords | アストロサイト / ミクログリア / ニューロン / ガングリオシド / 神経変性 / 炎症 |
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| Research Abstract |
Gangliosides (acidic glycosphingolipids) expressed on the plasma membrane are highly expressed in nerve tissues of vertebrates, and are involved in their development and functions. Our study clarified that glial cells components of nerve tissues, also express gangliosides on the plasma membrane, and glial cells in gangliosides-deficient mice were abnormally activated in the brain and enhanced sensitivity for inflammatory cytokines.
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Research Products
(17 results)
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[Journal Article] C9-R95X Polymorphism in Patients with Neovascular Age-Related Macular Degeneration2012
Author(s)
Koji Nishiguchi, Tetsuhiro Yasuma, Daisuke Tomida, Makoto Nakamura, Kohei Ishikawa, Masato Kikuchi, Yuhsuke Ohmi, Toshimitsu Niwa, Nobuyuki Hamajima, Koichi Furukawa, and Hiroko Terasaki
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 53(1)
Pages: 508-12
Peer Reviewed
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