2012 Fiscal Year Final Research Report
Mechanism of loss of function by nucleophosmin mutation in AML patients
| Project/Area Number |
23790367
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Shimane University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 分子病態学 |
|---|
| Research Abstract |
Nucleolar protein nucleophosmin was associated with ribosomal protein RPL22 through its C-terminal region. This association was not direct but mediated by RNA. Both cellular localization nor association with RPL22 were influenced by phosphorylation on C-terminal region of nucleophosmin. However, mutant nucleophosmin found in AML patients, did not associate with RPL22.
|
