2012 Fiscal Year Final Research Report
ATF1 modulate Heat shock response regulated by HSF1 activity.
| Project/Area Number |
23790368
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TAKII Ryousuke 山口大学, 大学院・医学系研究科, 助教 (00419558)
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| Project Period (FY) |
2011 – 2012
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| Keywords | HSF1 / 転写因子 / ストレス応答 |
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| Research Abstract |
To identify HSF1 activation mechanisms, we screened HSF1 binding protein and we identified that ATF1 (activating transcription factor 1) functioned important role during heat shock. In MEF (mouse embryonic fibroblasts), ATF1 and CREM is required for heat-inducible HSP70 expression during heat shock and attenuation of HSF1 activity in recovery after heat shock. Then ATF1 is recruited to HSP70 promoter region during heat shock depend on HSF1 and ATF1 is necessary to recruit BRG1 and p300/CBP.
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[Journal Article] Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation2011
Author(s)
Shinkawa T, Tan K, Fujimoto M, Hayashida N, Yamamoto K, Takaki E, Takii R, Prakasam R, Inouye S, Mezger V, Nakai A
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Journal Title
Mol Biol Cell
Volume: 22
Pages: 3571-3583
Peer Reviewed
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