2014 Fiscal Year Final Research Report
Human mitochondrial DNA nucleoid machinery regulated by TFAM
Project/Area Number |
23790370
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | Nagasaki International University (2014) Kyushu University (2011-2013) |
Principal Investigator |
|
Project Period (FY) |
2011-04-28 – 2015-03-31
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Keywords | ミトコンドリア / ヌクレオイド / 翻訳後修飾 |
Outline of Final Research Achievements |
We demonstrated the importance of TFAM in functional regulation of human mitochondrial nucleoid and showed the machinery regulated by post-translational modification of TFAM. In addition, we observed the novel mechanism unique to mitochondrial acetylation. The mechanism in mitochondria was different from acetylation in nucleus and cytoplasm. By the mechanism, mitochondrial general protein were acetylated and were functionally regulated. Moreover, we identified that by the similar mechanism, mitochondrial protein were also succinylated and malonylated and were functionally regulated.
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Free Research Field |
生化学 分子生物学
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