2012 Fiscal Year Final Research Report
NDRG2 deficient mice induces tumor formation and lifestyle related disease through the activation of AKT phosphorylation
| Project/Area Number |
23790372
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | がん / 成人病 / AKT |
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| Research Abstract |
We reported that NDRG2 (N-myc downstream-regulated gene 2) is a candidate for tumor suppressor gene in ATLL(adult T-cell leukemia-lymphoma), which can modulate signal transduction of PI3K/AKT pathway. NDRG2 deficient mice developed various type of tumor with increased phosphorylated AKT in all organs. Furthermore, we indicated that NDRG2 deficient mice associated with lifestyle related disease such as brain disease, cardiac hypertrophy and fatty liver. These finding suggest thatNDRG2 may become a new therapeutic target for many type of disease
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