2012 Fiscal Year Final Research Report
Investigation of the mechanism underlying the effect of leptin on colorectal carcinogenesis
| Project/Area Number |
23790374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
ENDO Hiroki 横浜市立大学, 附属病院, 助教 (70468164)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 大腸発がん / レプチン |
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| Research Abstract |
We clarified that leptin acts as a growth factor for colorectal cancer at stages subsequent to tumour initiation in colon carcinogenesis via leptin receptor/STAT3 pathway which was not activated in normal colonic epithelium and premalignant lesions because of lack of the leptin receptors, and then Wnt signalling contributes to the upregulation of leptin receptors in colonic epithelium.
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Research Products
(19 results)
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[Journal Article] Eicosapentaenoic acid (EPA) efficacy for colorectal aberrant crypt foci (ACF): a double-blind randomized controlled trial2012
Author(s)
Higurashi T, Hosono K, Endo H, Takahashi H, Iida H, Uchiyama T, Ezuka A, Uchiyama S, Yamada E, Ohkubo H, Sakai E, Maeda S, Morita S, Natsumeda Y, Nagase H, Nakajima A
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Journal Title
BMC Cancer
Volume: 12(1)
Pages: 413
DOI
Peer Reviewed
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[Journal Article] Number of aberrant crypt foci in the rectum is a useful surrogate marker of colorectal adenoma recurrence2012
Author(s)
Uchiyama T, Takahashi H, Endo H, Kato S, Sakai E, Hosono K, Yoneda M, Inamori M, Hippo Y, Nakagama H, Nakajima A
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Journal Title
Dig Endosc
Volume: 24(5)
Pages: 353-7
DOI
Peer Reviewed
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[Journal Article] Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial2012
Author(s)
Higurashi T, Takahashi H, Endo H, Hosono K, Yamada E, Ohkubo H, Sakai E, Uchiyama T, Hata Y, Fujisawa N, Uchiyama S, Ezuka A, Nagase H, Kessoku T, Matsuhashi N, Nakayama S, Inayama Y, Morita S, Nakajima A
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Journal Title
BMC Cancer
Volume: 12(1)
Pages: 118
DOI
Peer Reviewed
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[Journal Article] Identification of preneoplastic lesions as mucin-depleted foci in patients with sporadic colorectal cancer2012
Author(s)
Sakai E, Morioka T, Yamada E, Ohkubo H, Higurashi T, Hosono K, Endo H, Takahashi H, Takamatsu R, Cui C, Shiozawa M, Akaike M, Samura H, Nishimaki T, Nakajima A, Yoshimi N
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Journal Title
Cancer Sci
Volume: 103(1)
Pages: 144-9
DOI
Peer Reviewed
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[Journal Article] Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression2011
Author(s)
Uchiyama T, Takahashi H, Endo H, Sugiyama M, Sakai E, Hosono K, Nagashima Y, Inayama Y, Wada K, Hippo Y, Nakajima A
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Journal Title
Int J Oncol
Volume: 39(4)
Pages: 935-40
DOI
Peer Reviewed
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[Journal Article] Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis2011
Author(s)
Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H, Nakajima A
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Journal Title
Gut
Volume: 60(10)
Pages: 1363-71
DOI
Peer Reviewed
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[Presentation] The histopathological characteristics of mucin-depleted foci in patients with sporadic colorectal cancer2012
Author(s)
akai E, Takahashi H, Yamada E, Higurashi T, Ohkubo H, Hosono K, Endo H, Kato S, Nakajima A, Cui C, Takamatsu R, Yoshimi N
Organizer
AACR 2012 (pathogenesis of gastrointestinal and hepatocellular carcinomas)
Place of Presentation
Chicago, U.S.A
Year and Date
2012-04-02
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[Presentation] Validity of ACF using as a surrogate biomarker for colorectal cancer2011
Author(s)
Sakai E, Takahashi H, Kato S, Uchiyama T, Hosono K, Endo H, Maeda S, Yoneda M, Taguri M, Nakajima A
Organizer
AACR conference on frontiers in cancer prevention research, poster session
Place of Presentation
Boston, U.S.A.
Year and Date
2011-10-03
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