2012 Fiscal Year Final Research Report
Pathological analyses of developmental mechanisms and proposal fora new breast neuroendocrine tumor (B-NET) classification
Project/Area Number |
23790394
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human pathology
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Research Institution | University of Yamanashi |
Principal Investigator |
KAWASAKI Tomonori 山梨大学, 大学院・医学工学総合研究部, 助教 (90456484)
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Project Period (FY) |
2011 – 2012
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Keywords | 泌尿生殖器 / 内分泌 |
Research Abstract |
We first described widely distributed normal-lookingneuroendocrine (NE) cells showing isolated/scattered, clustered and/or circumferentialemerging patterns in background tissues of some breast NE tumors (B-NET) including NEductal carcinoma in situ (NE-DCIS). These novel findings could be regarded asrepresenting “NE cell hyperplasia” relevant to B-NET development as a precancerouslesion. In addition, we reported low-grade B-NET closely associated with intraductalpapilloma and high-grade B-NET containing conventional in situ ductal carcinoma foci.Thus, we have shown that multiple mechanisms are involved in the development of B-NET.
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[Journal Article] Expression of MHCClass I on breast cancer cellscorrelates inversely with HER2expression2012
Author(s)
Inoue M, Mimura K, Izawa S, ShiraishiK, Inoue A, Shiba S, Watanabe M,Maruyama T, Kawaguchi Y, Inoue S,Kawasaki T, et al
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Journal Title
OncoImmunology
Volume: 1
Pages: 1104-10
Peer Reviewed
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[Presentation] 高齢者乳癌の検討2011
Author(s)
井上正行, 井上慎吾, 井上亜矢子, 丸山孝教, 松田啓, 川崎朋範ら
Organizer
第19回日本乳癌学会学術総会
Place of Presentation
仙台
Year and Date
2011-09-02
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[Remarks] 第18回山梨科学アカデミー奨励賞 (山梨科学アカデミー) (2013年)
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[Remarks] 平成 23年度日本病理学会学術奨励賞(日本病理学会) (2012年)
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[Remarks] 日本臨床細胞学会 平成24年最優秀論文賞 (日本臨床細胞学会) (2012年)
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[Remarks] 第17回日本乳癌学会研究奨励賞 (日本乳癌学会) (2011年)
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[Remarks] 平成23年度優秀教員奨励制度「特別表彰」(山梨大学) (2011年)
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