Technological research and applied analysis of genomic instability in tumor-susceptible individuals

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790396
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: KAHYO Tomoaki 浜松医科大学, 医学部, 助教 (40416665)
• Project Period (FY): 2011 – 2012
• Keywords: 分子病理 / 腫瘍

Research Abstract

The inverse PCR method targeting the long terminal repeat (LTR) region conserved among human endogenous retroviruses (HERVs) was performed to assess genomic instability in tumor-susceptible individuals. As a result, two novel insertional polymorphisms of solo LTR were identified . Interestingly , one of the two insertional polymorphisms, located on chromosome 1p13.2, was involved with the susceptibility to lung adenocarcinoma of female never-smokers in an age-dependent manner. Further study of epigenetic effects on the LTR region will be necessary

Research Products

• [Presentation] Analysis of novel insertion polymorphisms of human endogenous retrovirus in lung cancer patients (2013)
  • Author(s): Tomoaki Kahyo et al
  • Organizer: American Association for Cancer Research Annual Meeting 2013
  • Place of Presentation: Washington D.C.(米国)
  • Year and Date: 2013-04-06
• [Presentation] 肺癌および大腸癌患者における新規 HERV 挿入多型の同定と解析 (2012)
  • Author(s): Tomoaki Kahyo et al.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] 肺がんおよび大腸がん患者における新規 HERV 挿入多型の解析 (2012)
  • Author(s): Tomoaki Kahyo et al.
  • Organizer: 平成 24 年度がん若手研究者ワークショップ
  • Place of Presentation: 茅野
  • Year and Date: 2012-09-05
• [Presentation] Identification and analysis of novel polymorphic insertions of human endogenous retroviruses in lung cancers (2011)
  • Author(s): Tomoaki Kahyo et al
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14