2012 Fiscal Year Final Research Report
Clarification of biological features of ovarian clear cell carcinoma
| Project/Area Number |
23790405
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 卵巣明細胞腺癌 / 酸化ストレス / 遺伝子異常 |
|---|
| Research Abstract |
We evaluated immunohistochemical expression of oxidative stress markers (COX2、iNOS、8-OHdG) in ovarian clear cell adenocarcinomas. With respect to clear cell-dominant clear cell adenocarcinomas, the immunopositivity for COX2, iNOS and 8-OHdG were 62%、36%、55%, respectively. With respect to oxyphilic cell-dominant clear cell adenocarcinomas, the immunopositivity for COX2, iNOS and 8-OHdG were 77%、67%、77%, respectively. With respect to endometrioid adenocarcinomas, the immunopositivity for COX2, iNOS and 8-OHdG were 75%、65%、0%, respectively. However, the immunopositivity for 8-OHdG in clear cells of endometrioid adenocarcinomas were 66%. It is suggested that ovarian clear cell adenocarcinomas are affected by oxidative stress. 8-OHdG immunopositivity appeared to correlated with cytoplasmic clear cell change of carcinoma cells
|
