2012 Fiscal Year Final Research Report
Genomic profiling of renal cell carcinoma in patients with end-stage renal disease
| Project/Area Number |
23790408
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Oita University |
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Principal Investigator |
INOUE Toru 大分大学, 医学部, 客員研究員 (90468009)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 分子病理 |
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| Research Abstract |
The purpose of this study was to determine the genomic profile of renal cell carcinoma in end-stage renal disease (RCC-ESRD) by analysis of genomic copy number aberrations (CNAs). Seventy-nine tumor samples from 63 patients with RCC-ESRD were analyzed by array comparative genomic hybridization (array CGH) using the Agil ent Whole Human Genome 4×44K Oligo Micro Array. Unsupervised hierarchical clustering analysis revealed that the 63 cases were divisible into two groups: clusters A and B. Cluster A comprised mainly clear cell RCCs (CCRCCs), whereas cluster B comprised mainly papillary RCCs (PRCCs), acquired cystic disease (ACD)-associated RCCs and clear cell papillary RCCs. Analysis of the averaged frequencies revealed that the genomic profiles of clusters A and B resembled those of sporadic CCRCC and sporadic papillary RCC (PRCC), respectively. Although, on the basis of histopathology, it has been proposed that ACD-associated RCC, clear cell papillary RCC and PRCC-ESRD are distinct subtypes, our present data reveal that their genomic profiles categorized as cluster B resemble one another. Furthermore, genomic profiles of PRCC, ACD-associated RCC and clear cell papillary RCC admixed in one tissue tended to resemble one another. On the basis of genomic profiling of RCC-ESRD, we conclude that the molecular pathogenesis of CCRCC-ESRD resembles that of sporadic CCRCC. Although various histologic subtypes of non-CCRCC-ESRD have been proposed, their genomic profiles resemble those of sporadic PRCC, suggesting that the molecular pathogenesis of non-CCRCC-ESRD might be related to that of sporadic PRCC.
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Research Products
(2 results)
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[Journal Article] Genomic profiling of renal cell carcinoma in patients with end-stage renal disease2012
Author(s)
Toru Inoue, Keiko Matsuura, Taichiro Yoshimoto, Lam Tung Nguyen, Yoshiyuki Tsukamoto, Chisato Nakada, Naoki Hijiya, Takahiro Narimatsu, Takeo Nomura, Fuminori Sato, Yoji Nagashima, Kenji Kashima, Shingo Hatakeyama, Chikara Ohyama, Kazuyuki Numakura, Tomonori Habuchi, Masayuki Nakagawa, Masao Seto, Hiromitsu Mimata and Masatsugu Moriyama
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Journal Title
Cancer Science
Volume: 103巻 3 号
Pages: 569-575
Peer Reviewed
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