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2013 Fiscal Year Final Research Report

Molecular Mechanisms in extravasation of nanoDDS

Research Project

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Project/Area Number 23790433
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionOkayama University (2012-2013)
The University of Tokyo (2011)

Principal Investigator

KANO Mitsunobu  岡山大学, 医歯(薬)学総合研究科, 教授 (80447383)

Project Period (FY) 2011-04-28 – 2014-03-31
Keywords腫瘍血管 / ナノDDS
Outline of Final Research Achievements

We have shown that characteristics of tumor vasculature can determine the intractability of tumors, and that manipulation of the vasculature characteristics can improve the efficacy of nanoDDS in the animal models of pancreatic and gastric cancers. In this study we focused on a protein, known to be expressed in neovasculature and stabilizing endothelial-mural cell attachment. The protein was suggested to play an important role in the mechanism of extravasation of nanoDDS from tumor vasculature.

Free Research Field

医歯薬学

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Published: 2016-06-03   Modified: 2016-09-08  

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