2013 Fiscal Year Final Research Report
Molecular Mechanisms in extravasation of nanoDDS
| Project/Area Number |
23790433
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Okayama University (2012-2013)
The University of Tokyo (2011) |
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Principal Investigator |
KANO Mitsunobu 岡山大学, 医歯(薬)学総合研究科, 教授 (80447383)
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| Project Period (FY) |
2011-04-28 – 2014-03-31
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| Keywords | 腫瘍血管 / ナノDDS |
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| Outline of Final Research Achievements |
We have shown that characteristics of tumor vasculature can determine the intractability of tumors, and that manipulation of the vasculature characteristics can improve the efficacy of nanoDDS in the animal models of pancreatic and gastric cancers. In this study we focused on a protein, known to be expressed in neovasculature and stabilizing endothelial-mural cell attachment. The protein was suggested to play an important role in the mechanism of extravasation of nanoDDS from tumor vasculature.
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| Free Research Field |
医歯薬学
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