2012 Fiscal Year Final Research Report
Regulatory mechanism of signal transduction involved in cytokine production from basophils and the control of type 2 immune response.
| Project/Area Number |
23790438
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Shinshu University |
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Principal Investigator |
SANJO Hideki 信州大学, 医学部, 助教 (50391967)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 好塩基球伝達 / サイトカイン / シグナル |
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| Research Abstract |
The aim of this study is to reveal the unknown molecular mechanisms of signaling pathway that regulate activation of basophils, important for type 2 immune response, as well as cytokine production.
As a result the regulatory mechanisms were evident that the resting basophils restrain the signal transduction via FcεRI, a receptor for IgE, by negatively regulating the protein levels of signaling molecules and Bcl6, known as transcriptional corepressor
negatively regulates cytokine production induced by FcεRI crosslinking in the resting basophils.
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