2012 Fiscal Year Final Research Report
Experimental study of cellular damage and carcinogenesis of hepatocyte
Project/Area Number |
23790449
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
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Research Institution | Nagoya City University |
Principal Investigator |
NAIKI Aya 名古屋市立大学, 大学院・医学研究科, 助教 (20509236)
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Project Period (FY) |
2011 – 2012
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Keywords | ギャップ結合 / 肝発がん / 動物モデル |
Research Abstract |
Connexin 32 (Cx32) is a major gap junction protein in the liver. We established Cx32 dominant negative transgenic rats and Cx32 transfected rat hepatocellular carcinoma cells. The present study by using them indicated that caspase 3 dependent apoptosis was an important mechanism of acetaminophen-induced hepatotoxicity. Moreover, Cx32 regulates apoptotic signaling in both normal liver tissue and hepatocellular carcinoma cells, may play important roles in preventing carcinogenesis by inducing apoptosis in genetically damaged cells with cancer initiation.
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Research Products
(14 results)
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[Journal Article] TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 andtransglutaminase 22012
Author(s)
Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 109
Pages: 4332-5
DOI
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[Journal Article] Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellularcarcinoma cells2012
Author(s)
Ogawa K, Pitchakarn P, Suzuki S, Chewonarin T,Tang M, Takahashi S, Naiki-Ito A, Sato S, Takahashi S, Asamoto M, Shirai T
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Journal Title
Cancer Sci
Volume: 103
Pages: 860-7
DOI
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