2013 Fiscal Year Final Research Report
Study for the mechanism of HIV-1 latent infection in a humanized mouse model
| Project/Area Number |
23790453
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | HIV / ヒト化マウス / T細胞 |
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| Research Abstract |
This study was aimed at elucidating the mechanism of latent infection of HIV-1 by analyzing a humanized mouse model. Humanized mice were challenged with CXCR4-tropic (X4) and/or CCR5-tropic (R5) HIV-1. We found that R5 HIV-1 preferentially targeted to activated memory CD4+ T cells irrespective of X4 HIV-1. In contrast, although X4 HIV-1 substantially infected to activated memory CD4+ T cells, the infection efficiency in the cell population was markedly reduced in the presence of R5 HIV-1. These results suggest that the respective X4 and R5 HIV-1 reservoirs are formed from different subsets of CD4+ T cells.
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[Journal Article] Sensitive detection of measles virus infection in the blood and tissues of humanized mouse by one-step quantitative RT-PCR2013
Author(s)
S. Ikeno, M. Suzuki, M. Muhsen, M. Ishige, M. Kobayashi, S. Ohno, M. Takeda, T. Nakayama, Y. Morikawa, K. Terahara, S. Okada, H. Takeyama, Y. Tsunetsugu-Yokota
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Journal Title
Frontiers in Microbiology
Volume: 4
Pages: 298
DOI
Peer Reviewed
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[Journal Article] HIV-1 infection ex vivo accelerates measles virus infection by upregulating signaling lymphocytic activation molecule (SLAM) in CD4^+ T cells2012
Author(s)
Y. Mitsuki, K. Terahara, K. Shibusawa, T. Yamamoto, T. Tsuchiya, F. Mizukoshi, M. Ishige, S. Okada, K. Kobayashi, Y. Morikawa, T. Nakayama, M. Takeda, Y. Yanagi, Y. Tsunetsugu-Yokota
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Journal Title
Journal of Virology
Volume: 86
Pages: 7227-7234
DOI
Peer Reviewed
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[Journal Article] Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in Burmese rhesus macaques2012
Author(s)
T. Nomura, H. Yamamoto, T. Shiino, N. Takahashi, T. Nakane, N. Iwamoto, H. Ishii, T. Tsukamoto, M. Kawada, S. Matsuoka, A. Takeda, K. Terahara, Y. Tsunetsugu-Yokota, N. Iwata-Yoshikawa, H. Hasegawa, T. Sata, T. Naruse, A. Kimura, T. Matano
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Journal Title
Journal of Virology
Volume: 86
Pages: 6481-6490
DOI
Peer Reviewed
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