2013 Fiscal Year Final Research Report
Analysis of bacteria-like ferrochelatases in animal parasitic nematodes
| Project/Area Number |
23790461
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 糞線虫 / フェロケラターゼ / ヘム合成 / 動物寄生線虫 / 遺伝子水平伝播 |
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| Research Abstract |
It had been thought that nematodes are unable to synthesize heme, lacking all enzyme genes necessary for heme biosynthesis. However our analysis of Strongyloides (an animal parasitic nematode) genome and those of other nematode species indicated some animal parasitic nematode species possess genes that encode ferrochelatase (FeCH), an enzyme which medicates the terminal step of the heme biosynthesis.
Interestingly, nematode FeCH amino acid sequence showed more similarity to bacterial FeCH rather than to eukaryotic FeCH. Our results indicated some animal parasitic nematode species acquired FeCH gene from bacteria by horizontal gene transfer for a certain nutritional necessity at some point in their evolutionally histories.
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Research Products
(15 results)
