2013 Fiscal Year Final Research Report
Elucidation of hematopoietic disturbance in malaria
| Project/Area Number |
23790462
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | γδ T細胞 / 樹状細胞 / マラリア / IFN-γ / CD40 Ligand / 造血 |
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| Research Abstract |
In this study, by analyses using gamma delta T cell-deficient mice (TCR-delta KO mice) with plasmodium infection, we suggest that gamma delta T cell would be involve in splenic hematopoiesis after infection with Plasmodium berghei XAT. On the other hands, after infection with the parasites, we observed higher proportion of hematopoietic cells in peripheral blood of TCR-delta KO mice than that of WT mice. This result suggests that gamma delta T cells would be involved in homing of hematopoietic cells to spleen after infection with the parasites. However, to elucidate of the mechanisms for gamma delta T cell-related hematopoiesis in malaria. Furthermore, in the process of this study, we elucidated that CD40 Ligand and IFN-gamma-producing gamma delta T cells enhance dendritic cell activation, resulting in protective immunity against Plasmodium berghei XAT.
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