2012 Fiscal Year Final Research Report
Research on geographical origin and spread of drug resistant Plasmodium vivax in Asia
| Project/Area Number |
23790465
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
IWAGAMI Moritoshi 独立行政法人国立国際医療研究センター, 熱帯医学マラリア研究部, 上級研究員 (20392392)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 三日熱マラリア原虫 / 薬剤耐性 / 分子疫学研究 / クロロキン / アジア |
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| Research Abstract |
Genetic polymorphisms of chloroquine (CQ) resistant gene and the polymorphisms flanking the gene of Plasmodium vivax in Asia were examined. All the isolates from the Philippines where treatment failure to CQ had never been reported possessed resistant genotype. On the other hand, all the isolates from the Republic of Korea where treatment failure to CQ had been reported possessed susceptible genotype. These results suggested that the polymorphisms of the resistant gene were local genotypes and that the association between the genotypes and CQ susceptibility were elusive.
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[Journal Article] First case of Plasmodium knowlesi infection in a Japanese traveller returning from Malaysia.2013
Author(s)
Tanizaki R, Ujiie M, Kato Y, Iwagami M, Hashimoto A, Kutsuna S, Takeshita N, Hayakawa K, Kanagawa S, Kano S, Ohmagari N
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Journal Title
Malaria Journal
Volume: Vol.12
Pages: 128
DOI
Peer Reviewed
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