2013 Fiscal Year Final Research Report
Characterization of bacterial collagen sensor and adhesin for screening of new matrix anchors
| Project/Area Number |
23790483
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Okayama University (2012-2013)
Kitasato University (2011) |
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Principal Investigator |
MIMA Takehiko 岡山大学, 医歯(薬)学総合研究科, 助教 (80596437)
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| Project Period (FY) |
2011 – 2013
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| Keywords | コラゲナーゼ / ビブリオ / 発現調節 / 二成分制御系 / 遺伝子発現 / 毒素 |
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| Research Abstract |
Vibrio alginolyticus produces collagenase only when collagen is present. This shows that V. alginolyticus possesses the sensor for collagen. Isolating mutants that are deficient in collagenase production using newly invented method identified genes that regulate production of collagenase in V. alginolyticus. As the result, two-component regulatory system was identified to regulate the expression of collagenase in V. alginolyticus.
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