2012 Fiscal Year Final Research Report
Non-enveloped virus release by intracellular membrane trafficking
| Project/Area Number |
23790503
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
MORITA Eiji 大阪大学, 微生物病研究所, 特任准教授 (70344653)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞 / メンブレントラフィック |
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| Research Abstract |
In this study, we identified that dominant negative expression or gene disruption of autophagy (ATG) genes negatively regulates the viral like particle production from the cells. We also confirmed that several viral protein positive compartments are co-localizes with LC3s, markers for autophagosome. These results suggest that the cellular autophagy pathway are involved in the virus particle release in infected cells.
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[Journal Article] Japanese Encephalitis Virus Core Protein Inhibits Stress Granule Formation through an Interaction with Caprin-1 and Facilitates Viral Propagation2013
Author(s)
Katoh, H., Okamoto, T., Fukuhara, T., Kambara, H., Morita, E., Mori, Y., Kamitani, W., Matsuura, Y
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Journal Title
J Virol
Volume: 87(1)
Pages: 489-502
DOI
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[Journal Article] Proteomic analysis of hepatitis C virus (HCV) core protein transfection and host regulator PA28 knockout in HCV pathogenesis: a network-based study2012
Author(s)
Tripathi, L.P., Kambara, H., Moriishi, K., Morita, E., Abe, T., Mori, Y., Chen, Y.A., Matsuura, Y., Mizuguchi, K
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Journal Title
J Proteome Res
Volume: 11(7)
Pages: 3664-79
DOI
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[Journal Article] Expression of microRNA miR-122 facilitates an efficient replication in nonhepatic cells upon infection with hepatitis C virus2012
Author(s)
Fukuhara, T., Kambara, H., Shiokawa, M., Ono, C., Katoh, H., Morita, E., Okuzaki, D., Maehara, Y., Koike, K., Matsuura, Y.
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Journal Title
J Virol
Volume: 86(15)
Pages: 7918-33
DOI
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[Journal Article] Heterogeneous nuclear ribonucleoprotein A2 participates in the replication of Japanese encephalitis virus through an interaction with viral proteins and RNA2011
Author(s)
Katoh, H., Mori, Y., Kambara, H., Abe, T., Fukuhara, T., Morita, E., Moriishi, K., Kamitani, W., Matsuura, Y.
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Journal Title
J Virol.
Volume: 85
Pages: 10976-10988
DOI
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