2012 Fiscal Year Final Research Report
Molecular mechanism of anti-HIV-1 activity mediated by Rac2
| Project/Area Number |
23790510
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | ウイルス / HIV-1 / rac2 / 感染抵抗性因子 / 感染制御 |
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| Research Abstract |
We identified a new function of human Rac2. Rac2 negatively or positively regulates several cytokines production at transcriptional level. The transcriptional regulation by Rac2 involves specific molecules acting in cellular signal transduction pathway. The regulation of inflammatory cytokines would be the one of mechanisms by which Rac2 mediates the anti-HIV-1 activity. We found that Rac2 associates with viral proteins which can control autophagy. These interactions implied that Rac2 suppresses HIV-1 replication thorough modification of cellular autophagy activity controlled by viral proteins.
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