2012 Fiscal Year Final Research Report
Developing a new cell culture system for efficient production of infectious HPV virions to study molecular mechanisms of HPV infection cycles.
| Project/Area Number |
23790517
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
NAKAHARA Tomomi 独立行政法人国立がん研究センター, 研究所, 研究員 (60601177)
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| Project Period (FY) |
2011 – 2012
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| Keywords | パピローマウイルス / 複製 / ATM / NF-κB |
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| Research Abstract |
The life cycle of human papillomavirus (HPV), an etiological agent of cervical cancer, relied upon host cell differentiation, hindering production of infectious HPV virions in a laboratory. The aims of this research are to develop a new cell culture system for efficient production of infectious HPV virions and to study molecular mechanisms of HPV replication cycles. We were able to manipulate cells to induce HPV genome amplification and found that activation of cellular DNA damage response including ATM and NF-κB can suppress HPV genome replication.
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