Study on the interaction between M cells and immune cells in Peyer' spatch.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790521
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Hokkaido University
• Principal Investigator: KIMURA Shunsuke 北海道大学, 大学院・医学研究科, 助教 (40444525)
• Project Period (FY): 2011 – 2012
• Keywords: パイエル板 / M細胞

Research Abstract

Peyer's patch (PP) in the small intestine is a primary site for the intestinal immune system. The luminal side of PPs is covered by the follicle-associated epithelium (FAE), which contains M cells, which uptake antigens or macromolecules, and deliver them to dendritic cells inhabiting subepithelial dome region under FAE. CCR1 is a receptor of Ccl9 which is belonging to the CC chemokine family and highly expressed in M cells. We found that CCR1 positive cells inhabit subepithelial dome region, and some of them contact with M cells. Moreover, our study suggests that CCR1 positive cell belongs to a subtype of antigen-producing plasma cells.

Research Products

• [Journal Article] The molecular basis of induction andformation of tunneling nanotubes (2013)
  • Author(s): Kimura S, Hase K, Ohno H
  • Journal Title: Cell Tissue Res Volume: 352(1) Pages: 67-76
  • DOI: doi:10.1007/s00441-012-1518-1.
  • Peer Reviewed
• [Journal Article] Tunneling nanotubes: Emerging view of their molecular components and formation mechanisms (2012)
  • Author(s): Kimura S, Hase K, Ohno H
  • Journal Title: Exp Cell Res Volume: 318(14) Pages: 1699-706
  • DOI: doi:10.1016/j.yexcr.2012.05.013.
  • Peer Reviewed
• [Journal Article] The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice (2011)
  • Author(s): Takahashi D, Hase K, Kimura S, Nakatsu F, Ohmae M, Mandai Y, Sato T, Date Y, Ebisawa M, Kato T, Obata Y, Fukuda S, Kawamura YI, Dohi T, Katsuno T, Yokosuka O, Waguri S, Ohno H
  • Journal Title: Gastroenterology Volume: 141(2) Pages: 621-32
  • DOI: doi:10.1053/j.gastro.2011.04.056.
  • Peer Reviewed
• [Presentation] The role of M-Sec in tunneling nanotube formation (2011)
  • Author(s): Hiroshi Ohno, Koji Hase, Shunsuke Kimura, Shuya Fukai
  • Organizer: the EMBO meeting
  • Place of Presentation: AustriaCenter (オーストリア)
  • Year and Date: 2011-09-11
• [Presentation] M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex (2011)
  • Author(s): Shunsuke Kimura, Takako Amada, Koji Hase, Toshihiko Iwanaga, Hiroshi Ohno
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 北海道大学(札幌)
  • Year and Date: 2011-06-29