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2012 Fiscal Year Final Research Report

Functions of posttranscriptional regulation of GATA3 in Th2 cells

Research Project

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Project/Area Number 23790522
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionChiba University

Principal Investigator

HOSOKAWA Hiroyuki  千葉大学, 大学院・医学研究院, 助教 (60431756)

Project Period (FY) 2011 – 2012
Keywordsアレルギー・ぜんそく / 発現制御 / Th2細胞 / GATA3 / 翻訳後修飾
Research Abstract

GATA3 controls differentiation of naive CD4 T cells into Th2 cells. However, the molecular mechanisms how GATA3 induces Th2 cell differentiation remain unclear. In this study, we found that GATA3 is phosphorylated and methylated in the zinc finger domains. Interestingly, the phosphorylated GATA3 could not repress Th1 cell differentiation and the activation of Il5 gene was selectively impaired in methylated GATA3. These results suggest that the regulation of posttranscriptional modifications of GATA3 may lead to the discovery of novel therapeutic targets for the treatment of allergic diseases with less side effects.

  • Research Products

    (15 results)

All 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (7 results)

  • [Journal Article] Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. Proc2013

    • Author(s)
      Hosokawa, H., Tanaka, T., Suzuki, Y., Iwamura, C., Ohkubo, S., Endoh, K., Kato, M., Endo, Y., Onodera, A., Tumes, D. J., Kanai, A., Sugano, S., and Nakayama, T.
    • Journal Title

      Natl. Acad. Sci. USA

      Volume: 110(12) Pages: 4691-4696

    • DOI

      DOI:10.1038/ni.2362

    • Peer Reviewed
  • [Journal Article] The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-b and suppresses TH2 differentiation2012

    • Author(s)
      Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D., Iwamura, C., Lefebvre, V., and Nakayama, T.
    • Journal Title

      Nat. Immunol

      Volume: 13 Pages: 778-786

    • DOI

      DOI:10.1038/ni.2362

    • Peer Reviewed
  • [Journal Article] Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development2012

    • Author(s)
      Lavial, F., Bessonnard, S., Ohnishi, Y.,Tsumura, A., Chandrashekran, A., Fenwick, M., Tomaz, R. A., Hosokawa, H., Nakayama, T., Chambers, I., Hiiragi, T., Chazaud, C., and Azuara, V.
    • Journal Title

      Genes Dev

      Volume: 26 Pages: 1445-1458

    • DOI

      DOI:10.1101/gad.188193.112

    • Peer Reviewed
  • [Journal Article] Type II membrane protein CD69 regulates the formation of resting T-helper memory2012

    • Author(s)
      Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Zehentmeier, S., Hosokawa, H., Iwamura, C., Koseki, H., Tumes, D. J., Radbruch, A., and Nakayama, T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Pages: 7409-7414

    • DOI

      DOI:10.1073/pnas.1118539109

    • Peer Reviewed
  • [Journal Article] Sublingual administration of Lactobacillus paracasei KW3110 inhibits Th2-dependent allergic responses via upregulation of PD-L2 on dendritic cells2012

    • Author(s)
      Inamine, A., Sakurai, D., Horiguchi, S., Yonekura, S., Hanazawa, T., Hosokawa, H., Matuura-Suzuki, A., Nakayama, T., and Okamoto, Y.
    • Journal Title

      Clin. Immunol

      Volume: 143 Pages: 170-179

    • DOI

      DOI:10.1016/j.clim.2012.01.008

    • Peer Reviewed
  • [Journal Article] Murine Schnurri-2 controls Natural Killer cell function and lymphoma development2012

    • Author(s)
      Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S., and Nakayama, T.
    • Journal Title

      Leuk. Lymphoma

      Volume: 53 Pages: 479-486

    • DOI

      DOI:10.3109/10428194.2011.625099

    • Peer Reviewed
  • [Journal Article] Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA32011

    • Author(s)
      Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, D. J., Tokoyoda, K., Hosokawa, H., Yamashita, M., and Nakayama, T.
    • Journal Title

      Immunity

      Volume: 35 Pages: 733-745

    • DOI

      DOI:10.1016/j.immuni.2011.08.017

    • Peer Reviewed
  • [Journal Article] Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA32011

    • Author(s)
      Horiuchi, S., Onodera, A., Hosokawa, H., Watanabe, Y., Tanaka, T., Sugano, S., Suzuki, Y., and Nakayama, T.
    • Journal Title

      J. Immunol

      Volume: 186 Pages: 6378-6389

    • DOI

      DOI:10.4049/jimmunol.1100179

    • Peer Reviewed
  • [Presentation] Epigenetic regulation of helper T cells by Polycomb and Trithorax complexes2013

    • Author(s)
      Onodera, A., Horiuchi, S., Sasaki, T., Hosokawa, H., Watanabe, Y., Suzuki, Y., and Nakayama, T.
    • Organizer
      International Symposium on Genome Science
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-01-09
  • [Presentation] CD69 regulates the formationof resting T-helper memory2012

    • Author(s)
      Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Hosokawa, H., Iwamura, C., Koseki, H., Tumes, D., Radbruch, A., and Nakayama, T.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-06
  • [Presentation] Genome-wide gene expression profiling revealed a critical role for GATA3 inthe maintenance of the Th2 cell phenotype2012

    • Author(s)
      Sasaki, T., Onodera, A., Hosokawa, H., Watanabe, Y., Horiuchi, S., Yamashita, J., and Nakayama, T.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-05
  • [Presentation] 中山俊憲GATA3/Ruvbl2複合体によるCdkn2c(p18,Ink4c)の転写制御を介したTh2細胞増殖制御メカニズムの解析2012

    • Author(s)
      細川裕之、田中知明、加藤美紀、遠山裕之、鈴木茜
    • Organizer
      第22回Kyoto T cell Conference
    • Place of Presentation
      京都
    • Year and Date
      2012-07-07
  • [Presentation] 肺炎球菌の血流感染及び肺炎における、IL-13による宿主防御の役割/Protective role of IL-13 in sepsis and respiratory infection against S. pneumoniae2011

    • Author(s)
      Yamamoto, N., DelaCruz, C., Takahashi, M., Fujita, T., Hosokawa, H., Nakayama, T., Akahori, Y., Yamamoto, H., Kawakami, K.,Askenase, W. P., and Kanemitsu, K.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-29
  • [Presentation] マウス Schnurri-2 は NK細胞の機能とリンパ腫の発症を制御する/Murine Schnurri-2 controls Natural Killer cell function and lymphoma development2011

    • Author(s)
      Yamashita, J., Iwamura, C., Hosokawa, H., Sasaki, T., Tumes, D., Motohashi, S., and Nakayama, T.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-28
  • [Presentation] STAT6によって誘導されるポリコ-ムとトライソラックスの置換反応/STAT6-mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance of GATA3 expression in Th2 cells2011

    • Author(s)
      Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Horiuchi, S., Watanabe, Y., and Nakayama, T.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-27

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Published: 2014-09-25  

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