2012 Fiscal Year Final Research Report
Characterization of intestinal microbiota for the treatment of inflammatory bowel disease
| Project/Area Number |
23790524
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research (2012)
The University of Tokyo (2011) |
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Principal Investigator |
ATARASHI Koji 独立行政法人理化学研究所, 免疫細胞システム研究グループ, 客員研究員 (60546787)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 制御性T 細胞 / 腸内細菌 / 炎症性腸疾患 |
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| Research Abstract |
Many studies suggest that altered intestinal microbiota may play a major role in the onset and exacerbation of several inflammatory diseases, including inflammatory bowel diseases (IBDs). We previously reported that murine commensal bacteria Clostridium spp. have the capacity to induce intestinal regulatory T (Treg) cells. This study was focused on the human intestinal bacteria which can induce Treg cells in the intestine. I successfully isolated the bacteria with the ability to induce Treg cells from human stool, and administration of these bacteria attenuated disease in models of colitis and allergic diarrhea.
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[Journal Article] Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II?restricted cytotoxic T lymphocytes.2013
Author(s)
Mucida D, Husain MM, Muroi S, van Wijk F, Shinnakasu R, Naoe Y, Reis BS, Huang Y, Lambolez F, Docherty M, Attinger A, Shui JW, Kim G, Lena CJ, Sakaguchi S, Miyamoto C, Wang P, Atarashi K, Park Y, Nakayama T, Honda K, Ellmeier W, Kronenberg M, Taniuchi I, Cheroutre H.
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Journal Title
Nat Immunol.
Volume: 14
Pages: 281-289
Peer Reviewed
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[Journal Article] Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine2013
Author(s)
Kusu T, Kayama H, Kinoshita M, Jeon SG, Ueda Y, Goto Y, Okumura R, Saiga H, Kurakawa T, Ikeda K, Maeda Y, Nishimura J, Arima Y, Atarashi K, Honda K, Murakami M, Kunisawa J, Kiyono H, Okumura M, Yamamoto M, Takeda K.
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Journal Title
J Immunol.
Volume: 190
Pages: 774-783
Peer Reviewed
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[Journal Article] Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses.2012
Author(s)
Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale ST, Honda K, and Taniguchi T.
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Journal Title
Nat Immunol.
Volume: 13
Pages: 659-666
Peer Reviewed
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