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2012 Fiscal Year Final Research Report

The role of eosinophil in the gut homeostasis

Research Project

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Project/Area Number 23790529
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NAKANISHI Yusuke  東京医科歯科大学, 難治疾患研究所, 特任講師 (20579411)

Project Period (FY) 2011 – 2012
Keywords粘膜免疫
Research Abstract

It is well known that eosinophil plays a critical role in the development of allergy or asthma. However, the role of eosinophil in the intestinal mucosa remains unknown. Here, we investigated the role of eosinophil in the development of ulcerative colitis, a representative inflammatory bowel disease (IBD). We found that, although eosinophil contributed to eliminate invading commensal bacteria, they did not play a major role in the development of ulcerative colitis.

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Published: 2014-09-25  

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