Thymic Sirpα^<+>DC subset conducts the novel process of intrathymic immune tolerance

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790532
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Kanazawa University
• Principal Investigator: BABA Tomohisa 金沢大学, がん進展制御研究所, 助教 (00452095)
• Project Period (FY): 2011 – 2012
• Keywords: 胸腺 / 樹状細胞 / 制御性T細胞

Research Abstract

The discrimination of self or non-self antigens is essential for the maintenance of intact immune system. In this study, we demonstrated that a thymic dendritic cell (DC) subset, Sirpα+ DC is the major conductor of the novel process of intrathymic immune tolerance against blood-borne antigens. Moreover, the secretory tumor-specific antigens can induce the intrathymic anti-tumor immune tolerance through the antigen presentation by thymic Sirpα+ DCs.

Research Products

• [Journal Article] Decrease of peripheral and intestinal NKG2A-positive T cells in patients with ulcerative colitis (2012)
  • Author(s): Katsurada T., Kobayashi W., Tomaru U., Baba T., Furukawa S., Ishizu A., Takeda K., Sakamoto N., Asaka M., Takeda H., Kasahara M
  • Journal Title: PLoS One Volume: 7 Pages: e44113
  • DOI: DOI:10.1371/journal.pone.0044113
  • Peer Reviewed
• [Journal Article] Novel process of intrathymic tumorimmune tolerance through CCR2-mediated recruitment of Sirpα+ dendritic cells: a murine model (2012)
  • Author(s): Baba T., Badr Mel S., Tomaru U., Ishizu A., Mukaida N
  • Journal Title: PLoS One Volume: 7 Pages: e41154
  • DOI: DOI:10.1371/journal.pone.0041154
  • Peer Reviewed
• [Journal Article] Chemokines in tumor development and progression (2012)
  • Author(s): Mukaida N., Baba T
  • Journal Title: Exp Cell Res Volume: 318 Pages: 95-102
  • DOI: DOI:10.1016/j.yexcr.2011.10.012
  • Peer Reviewed
• [Journal Article] Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity (2012)
  • Author(s): Wang YY., Taniguchi T., Baba T., Li YY., Ishibashi H., Mukaida N
  • Journal Title: Cancer Sci Volume: 103 Pages: 107-115
  • DOI: DOI:10.1111/j.1349-7006.2011.02117.x
  • Peer Reviewed
• [Presentation] Novel process of intrathymic immune tolerance against secretory tumorspecific antigens (2012)
  • Author(s): 馬場智久, 向田直史
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2012-12-05
• [Presentation] Thymic Sirp alpha+ DC subset conducts the novel process of intrathymic tumor-immune tolerance (2012)
  • Author(s): 馬場智久, 向田直史
  • Organizer: 第71回日本癌学会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-19
• [Presentation] Intrathymic perivascular dendritic 図2 血中抗原に対するcentral toleranceの誘導 cells capturing blood-borne antigens conduct central tolerance (2011)
  • Author(s): 馬場智久, 向田直史
  • Organizer: 第6回研究所ネットワーク国際シンポジウム
  • Place of Presentation: 東京医科歯科大学(東京都)
  • Year and Date: 2011-06-09
• [Remarks]
  • URL: http://www.kanazawa-u.ac.jp/~ganken/bunsiseitai/JapContent.html
• [Patent(Industrial Property Rights)] 慢性骨髄性白血病モデル動物 (2013)
  • Inventor(s): 馬場智久, 向田直史
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Number: 特願2013-011556
  • Filing Date: 2013-01-24