2012 Fiscal Year Final Research Report
PD-1 and novel immune-regulatory molecules in T cell differentiation.
| Project/Area Number |
23790534
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | T細胞 / 副刺激 / 免疫寛容 / 免疫抑制 / がん免疫 |
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| Research Abstract |
Biochemical and immunological experiments were carried out to elucidate roles of ITAG1, a novel molecule regulated by PD-1 during immune tolerance induction. I found that ITAG1 interacted with known transcriptional factor and chromatin regulators, suggesting its role in T cell differentiation. In contrast, ITAG1 knockout mice showed only minor defect, suggesting some compensatory mechanism in the knockout mice.
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[Journal Article]2012
Author(s)
Chikuma S, Suita N, Okazaki IM, Shibayama S, Honjo T
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Journal Title
Nat. Immunol.
Volume: 13
Pages: 596-603
DOI
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[Journal Article]2012
Author(s)
Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, Miyachi Y.
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Journal Title
J. Exp. Med
Volume: 209
Pages: 1743-52
URL
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[Journal Article]2011
Author(s)
Qin H, Suzuki K, Nakata M, Chikuma S, Izumi N, Huong LT, Maruya M, Fagarasan S, Busslinger M, Honjo T, Nagaoka H
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Journal Title
Plos One
Volume: 6
Pages: e29141
URL
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