2012 Fiscal Year Final Research Report
Function analysis of MASP-1 as a therapeutic target for lupus-pronenephritis in MRL/lpr mice
| Project/Area Number |
23790542
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
MACHIDA Takeshi 福島県立医科大学, 医学部・免疫学講座, 助教 (80583632)
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| Project Period (FY) |
2011 – 2012
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| Keywords | アレルギー・免疫関連疾患 / 全身性エリテマトーデス |
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| Research Abstract |
Lupus-prone MRL/lpr mice deficient for MASP-1, a serine protease essential for activation of the alternative complement pathway, were generated and analyzed for development of autoimmune lupus-prone disease. Aged MASP-1 KO MRL/lpr mice showed reduced serum C3 consumption, reduced serum anti-dsDNA levels, and no/moderate glomerulonephritis compared to age-matched wild-type littermates, indicating that suppression of MASP-1 would be an effective therapeutic strategy forhuman lupus nephritis.
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