2012 Fiscal Year Final Research Report
he role of histone modifications in the function and differentiaition of CD8 T cells
| Project/Area Number |
23790544
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
ARAKI Yasuto 埼玉医科大学, 医学部, 助教 (10580839)
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| Project Period (FY) |
2011 – 2012
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| Keywords | リンパ球 / CD8陽性T細胞 / T細胞分化 / エピゲノム |
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| Research Abstract |
In this study, we analyzed the mechanisms regulating histone modifications in the function and differentiation in CD8 T cells. We compared histone modifications and gene expressions by the genome-wide analyses in activated CD8 T cells. Both H3K4me3 and H3K9ac were positively correlated with gene expressions. The change in histone modifications in effector molecules after stimulation were associated with the effector function in CD8 T cells. Some histone methyltransferases and histone demethylases were upregluated and others were downregulated inCD8 T cells after stimulation. They were suggested to be associated with the change inhistone methylation in activated CD8 T cells. Together, the dynamic changes in histone methylation were supposed to regulate gene expressions in the function and differentiation in CD8 T cells.
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[Presentation] Histone methylation is associated with MMPs gene transcriptional activation in rheumatoid arthritis synovial fibroblasts.2012
Author(s)
Y. Araki, T. Wada, K. Sato, N. Kurosawa, K. Fujimoto, S. Suzuki, K. Yokota, F. Miyoshi, YT. Kim, H. Oda, R. Kurokawa, T. Mimura
Organizer
The 10th RCGM International Symposium of Academic
Place of Presentation
Commemoration Hall, Saitama Medcal University Hidaka Campus, Saitama, Japan
Year and Date
2012-11-03
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[Presentation] Dynamic changes of gene expression in concordance with histone modifications in CD8 T cells after activation2011
Author(s)
Subedi K, Araki Y, De S, Wood W, Sharov A, Zang C, Schones D, Lhotsky B, Dudekula D, Becker K, Ko M, Peng W, Zhao K, Weng NP
Organizer
98th The American Association of Immunologists Annual Meeting
Place of Presentation
the Moscone Center, San Francisco, California, USA.
Year and Date
2011-05-13
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