2012 Fiscal Year Final Research Report
The role for Rap1 signaling in the trafficking of germinal centerB cells
| Project/Area Number |
23790547
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 獲得免疫 / 胚中心 / 動態 / Rap1 |
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| Research Abstract |
We found that secondary antibody responses were enhanced in Rap1-effector RAPL and Mst1-/- mice. The fact that LFA-1-/- B cells showed normal germinal center and memory B cell generation suggests LFA-independent regulation of B cell response in enhanced antibody production of RAPL and Mst1-/- mice.
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