2012 Fiscal Year Final Research Report
Evaluation of the effect of M-cell deficiency by using M-cell-deficient mouse model.
| Project/Area Number |
23790550
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
KANAYA Takashi 独立行政法人理化学研究所, 免疫系構築研究チーム, 研究員 (20553829)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | M 細胞 / パイエル板 / 腸管免疫 |
|---|
| Research Abstract |
M cells have high capacity for phagocytosis and transcytosis, which enables the rapid transport of liminal antigen to underlying immune cells of Peyer’s patches. However, the importance of M cells in mucosal immune response has not been demonstrated. We have evaluated the effect of M-cell deficiency in mucosal immune response by using Spi-B-deficient mice (Spib KO), which completely lack functional M cells in Peyer’s patches. As a result of this, we confirmed that impaired immune response to Salmonella Typhimurium infection in Spib KO mice.
|
-
-
-
-
[Journal Article] The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.2012
Author(s)
Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, Hemmi H, Knoop KA, Kumar N, Sato M, Katsuno T, Yokosuka O, Toyooka K, Nakai K, Sakamoto A, Kitahara Y, Jinnohara T, McSorley SJ, Kaisho T, Williams IR, Ohno H.
-
Journal Title
Nat Immunol.
Volume: 13(8)
Pages: 729-36
DOI
Peer Reviewed
-
[Journal Article] Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis.2012
Author(s)
Obata Y, Takahashi D, Ebisawa M, Kakiguchi K, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, Hase K, Ohno H.
-
Journal Title
J Immunol.
Volume: 188(5)
Pages: 2427-36
DOI
Peer Reviewed
-
[Journal Article] Orally administered prion protein is incorporated by m cells and spreads into lymphoid tissues with macrophages in prion protein knockout mice.2011
Author(s)
Takakura I, Miyazawa K, Kanaya T, Itani W, Watanabe K, Ohwada S, Watanabe H, Hondo T, Rose MT, Mori T, Sakaguchi S, Nishida N, Katamine S, Yamaguchi T, Aso H.
-
Journal Title
Am J Pathol.
Volume: 179(3)
Pages: 1301-9
DOI
Peer Reviewed
-
-
-
-
-
-
