Cost-effectiveness of screening and treatment for sleep-disordered breathing

2013 Fiscal Year Final Research Report

• Project/Area Number: 23790567
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical sociology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: TAKEGAMI Misa 独立行政法人国立循環器病研究センター, 研究開発基盤センター, 研究員 (50456860)
• Project Period (FY): 2011 – 2013
• Keywords: 医療経済学 / 費用対効果 / スクリーニング / 睡眠呼吸障害 / 睡眠時無呼吸症候群

Research Abstract

Sleep-disordered breathing (SDB), including obstructive sleep apnea increase the risk of cardiovascular disease. Moreover, because it may lead to mo¬tor vehicle and public transportation accidents. SDB is therefore consid¬ered a problem requiring attention from both clinical and public health perspectives. However, there is controversy regarding the value of treatment for SDB patients free of symptoms. Using a Markov model, we examined the cost-effectiveness of screening for SDB in Japan. SDB screening was found to be cost-effective in the simulations, if society is willing to pay between 20,000 pound sterling and 30,000 pound sterling per 1 Quality-adjusted life year (QALY), which is the threshold used by the National Institute for Health and Clinical Excellence (NICE).

Research Products

• [Journal Article] Association between sleep apnea, sleep duration and serum lipid profile in an urban male working population in Japan (2013)
  • Author(s): Toyama Y, Chin K, Chihara Y, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka Y, Wakamura T, Fukuhara S, Mishima M, Kadotani H
  • Journal Title: Chest Volume: 143(3) Pages: 720-728
  • Peer Reviewed
• [Journal Article] Contribution of out-of-hospital factors to a reduction in cardiac arrest mortality due to witnessed ventricular fibrillation or tachycardia (2013)
  • Author(s): Nakamura F, Hayashino Y, Nishiuchi T, Kakudate N, Takegami M, Yamamoto Y, Yamazaki S, Fukuhara S
  • Journal Title: Rsuscitation Volume: 84(6) Pages: 747-751
  • Peer Reviewed
• [Journal Article] Relationships of Decreased Lung Function with Metabolic Syndrome and Obstructive Sleep Apnea in Japanese Males (2012)
  • Author(s): Yoshimura C, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka Y, Wakamura T, Fukuhara S, Mishima M, Kadotani H
  • Journal Title: Internal Medicin Volume: 51(17) Pages: 2291-2297
  • Peer Reviewed
• [Journal Article] Differences in relationships among sleep apnoea, glucose level, sleep duration and sleepiness between persons with and without type 2 diabetes (2012)
  • Author(s): Harada Y, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka Y, Wakamura T, Fukuhara S, Mishima M, Kadotani H
  • Journal Title: Journal of Sleep Research Volume: 21(4) Pages: 410-418
  • Peer Reviewed
• [Journal Article] Locomotor dysfunction and risk of cardiovascular disease, quality of life, medical cost : design of the Locomotive Syndrome and Health outcome in Aizu Cohort Study (LOHAS) and baseline characteristics of the study population (2012)
  • Author(s): Otani K, Takegami M, Fukumori N, Sekiguchi M, Onishi Y, Yamazaki S, Ono R, Otoshi K, Hayashino Y, Fukuhara S, Kikuchi S, Konno S, the LOHAS Research Group.
  • Journal Title: Journal of Orthopaedic Science Volume: 17(3) Pages: 261-271
  • Peer Reviewed
• [Journal Article] Work Performance Assessed by a Newly Developed Japanese Version of the Work Limitation Questionnaire in a General Japanese Adult Population
  • Author(s): Takegami M, Yamazaki S, Greenhill A, Chang H, Fukuhara S
  • Journal Title: Journal of Occupational Healtn Volume: (in press)
  • Peer Reviewed
• [Journal Article] Predicting Coronary Heart Disease Using Risk Factor Categories for a Japanese Urban Population, and Comparison with the ramingham Risk Score : The Suita Study
  • Author(s): Nishimura K, Okamura T, Watanabe M, Nakai M, Takegami M, Higashiyama A, Kokubo Y, Okayama A, Miyamoto Y
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: (in press)
  • Peer Reviewed
• [Presentation] LDL / HDLコレステロール比は虚血性心疾患の発症を予測するか (2014)
  • Author(s): 竹上未紗,渡邉至,小林貴,中井陸運,西村邦宏,小久保喜弘,宮本恵宏
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 20140000