2012 Fiscal Year Final Research Report
Development of an animal model for the developmental disorders, especially autism spectrum disorder, by the postnatal stressand its pharmacotherapeutic intervention
| Project/Area Number |
23790593
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | ストレス / 発達障害 / 自閉症 / モデル動物 / 社会的行動 / 幼児・児童虐待前臨床評価法 / 薬物治療 |
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| Research Abstract |
This study aimed at elucidating the pathophysiological mechanisms and establishing its preclinical drug evaluation for pharmacotherapy in the autism spectrum disorder, by investigating the validity as an animal model of the autism in rats experienced with postnatal stress. The findings in this study suggest that early postnatal stress might produce the social deficits in adolescent and postadolescent rats, indicating long-lasting changes of emotional susceptibilities possibly implicated in dysfunction of the GABAergic neuronal systems in the raphe nuclei. Furthermore, I established the new social interaction test in a single rat using a 3-compartment apparatus as new system to evaluate the rat social behaviors.
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[Journal Article] Milnacipran Enhances the Control of2013
Author(s)
Tsutsui-Kimura I., Ohmura Y., Izumi T., Kumamoto H., Yamaguchi T., Yoshida T, Yoshioka M.
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Journal Title
Impulsive Action by Activating D1-like Receptors in the Infralimbic Cortex. Psychopharmacology (Berl)
Volume: 225
Pages: 495-504
DOI
Peer Reviewed
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[Journal Article] Juvenile stress attenuates the dorsal hippocampal postsynaptic 5-HT1A receptor function in adult rats.2011
Author(s)
Matsuzaki H, Izumi T, Horinouchi T, Boku S, Inoue T, Yamaguchi T, Yoshida T, Matsumoto M, Togashi H, Miwa S, Koyama T, Yoshioka M
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Journal Title
Psychopharmacology (Berl)
Volume: 214
Pages: 329-337
DOI
Peer Reviewed
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[Journal Article] Serotonin1A receptor- madiated synaptic responses in the ratmedial prefrontal cortex is altered byearly life stress2011
Author(s)
Kimura S, Togashi H, Matsumoto M, Shiozawa T, Ishida J, Kano S, Ohashi A,Ishikawa S, Yamaguchi T, Yoshioka M,Shimamura K.
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Journal Title
In vivo and in vitro electrophysiological studies., Jpn JNeuropsychopharmacol.
Volume: 31
Pages: 9-15
URL
Peer Reviewed
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[Journal Article] Retrieval of conditioned fear activates the basolateral and intercalated nucleus of amygdala.2011
Author(s)
Izumi T, Boku S, Shinmin W, Inoue T, Konno K, Yamaguchi T, Yoshida T, Matsumoto M, Watanabe M, Koyama T, Yoshioka M.
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Journal Title
J Neurosci Res.
Volume: 89
Pages: 773-790
DOI
Peer Reviewed
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[Presentation] Anxiolytic effects of Yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced with aversive stress.2012
Author(s)
Yamaguchi T., Tsujimatsu A, Kumamoto H, Izumi T, Ohmura Y, Yoshida T, Yamamoto T. and Yoshioka M
Organizer
The 29th Collegium Internationale Neuro-psychopharmacologicum (CINP) World Congress, Brussels, Belgium, Int. J. Neuropsychopharmacol., 15 (Suppl. I),95-96, (
Place of Presentation
Stockholm, Sweden
Year and Date
20120603-0607
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