2012 Fiscal Year Final Research Report
Development of novel therapy for Parkinson's disease targeted toV-1 regulatory system of dopamine biosynthesis
| Project/Area Number |
23790594
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
KAWAHATA Ichiro 東北大学, 大学院・薬学研究科, 助教 (30579743)
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| Project Period (FY) |
2011 – 2012
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| Keywords | V-1 / tyrosine hydroxylase / dopa decarboxylase / dopamine / cofilin / MAL/SRF / RhoA / actin |
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| Research Abstract |
The applicant discovered an unknown expression system of dopamine (DA) biosynthesizing enzymes for development of novel therapy of Parkinson's disease (PD). This regulatory system was found to be operated by V-1 through MAL/SRF-mediated pathway coupled with activation of RhoA and acceleration of actin polymerization in vitro and in vivo. The basis of V-1 gene therapy for PD was successfully established in this work.
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