2013 Fiscal Year Final Research Report
Role of prostaglandin E2 in the development of cancer chemotherapeutic agents-induced side effects
| Project/Area Number |
23790598
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAMOTO Kouichi 大阪大学, 医学(系)研究科(研究院), 助教 (40362694)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 悪心・嘔吐 / 発症機構 / プロスタグランジン / サブスタンスP / ロイコトリエン |
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| Research Abstract |
Clinical reports demonstrated that nausea and vomiting occurs in many patients receiving cancer chemotherapy and surgery under general anesthesia. However, precise etiology of these symptoms are still unclear. To elucidate a possible mechanism, we tried to make an animal model of nausea and vomiting in rats and investigated the responsible neurotransmitters attributed to development of nausea and vomiting in rats. From a series of experiments, we confirmed that pica, kaolin ingestion behavior, is useful to evaluate nausea and vomiting in rats and prostaglandin E2, substance P and leukotriene may contribute to the development.
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