2012 Fiscal Year Final Research Report
Clinical application of the detection of the mutation in TSH receptor gene using a novel rapid gene analyzing method
| Project/Area Number |
23790614
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 遺伝子変異 / 甲状腺 / TSH / TSH 受容体 |
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| Research Abstract |
The R450H mutation in the TSH receptor gene (TSHR), observed frequently in Japanese patients with TSH resistance, may affect not only newborn but also adult thyroid function in Japanese. Detection of this mutation will be useful for examining the cause of hypothyroidism in Japanese. We developed the primer set to detect the R450H mutation in TSHR by a novel rapid gene analyzing technique, SmartAmp, investigated the frequency of this mutation and analyzed the association between this mutation and thyroid function in Japanese adults.
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[Journal Article] Association between accumulation of visceral fat and the combination of β3 adrenergic receptor Trp64Arg, β2 adrenergic receptor Arg16Gly and uncoupling protein 1 -3826A>G polymorphisms detected by Smart Amplification Process22011
Author(s)
Tsunekawa K, Yanagawa Y, Aoki T, Morimura T, Araki O, Ogiwara T, Kawai Y, Mitani Y, Lezhava A, Yanagawa M, Hayashizaki Y, Murakami M
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Journal Title
Endocr J
Volume: 58
Pages: 1079-86
Peer Reviewed
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