2012 Fiscal Year Final Research Report
Role of Moraxella catarrhalis outer membrane protein in antibiotic resistance and pathogenesis
| Project/Area Number |
23790616
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SAITO Ryoichi 東京医科歯科大学, 大学院・保健衛生学研究科, 准教授 (00581969)
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| Project Period (FY) |
2011 – 2012
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| Keywords | モラクセラ・カタラーリス / 外膜蛋白質 / 薬剤耐性 |
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| Research Abstract |
To contribute to the prevention and treatment of Moraxella catarrhalis infection, the present study was undertaken to investigate the function of M. catarrhalis OMPCD. Expression of OMPCD was found to be stable under various stress environments. Furthermore, our findings confirmed that OMPCD plays a role in bacterial physiology, including aspects such as bacterial growth and stabilization of bacterial cell morphology; penicillin resistance; and pathogenesis, such as adherence to human epithelial cells and serum resistance.
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Research Products
(3 results)
