2012 Fiscal Year Final Research Report
The relation between fibrinolytic abnormalities and the morphological changes in patients with aortic aneurysms
| Project/Area Number |
23790618
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OHTAKE Hiroshi 金沢大学, 医薬保健学総合研究科, 特任教授 (60283131)
MINAMI Tetsuya 金沢大学, 大学病院, 助教 (60436813)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 大動脈瘤 / 凝固線溶異常 |
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| Research Abstract |
We recruited consenting 64 patients with aortic aneurysms who had regularly visitedthe outpatient department of cardiovascular surgery in our hospital. We followed their clinical course, blood coagulation tents, and CT findings. 33 cases of endovascular repair, 26 cases of open repair, and eleven cases of no therapy were included. It revealed that plasma D-dimer levels increased before and after impendingrupture, endoleak of stentgrafting, and cerebrovascular disease. In aortic aneurysmpatients, the morphological changes of the lesion were thought to be deeply involved in the fobrinolytic abnormalities. Further evaluation is needed to assess the potential diagnostic and prognostic value of hemostatic and fibrinolytic markers in aortic aneurysm patients.
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[Journal Article] antithrombin deficiency: a novel frameshift mutation and a large deletion including all seven exons detected using two methods2011
Author(s)
Sekiya A, Morishita E, Karato M, Maruyama K, Shimogawara I, Omote M, Wakugawa Y, Shinohara M, Hayashi T,Two case reports of inherited Kadohira Y, Asakura H, Nakao S, Ohtake S.
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Journal Title
Int J Hematol
Volume: 93(2)
Pages: 216-9
DOI
Peer Reviewed
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