2012 Fiscal Year Final Research Report
Discovery of novel autoantibodies of fulminant type 1diabetes and autoimmune pancreatitis, the establishment of a measurement system.
| Project/Area Number |
23790620
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
TAKIZAWA Soichi 山梨大学, 医学工学総合研究部, 助教 (80456467)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 免疫血清学 |
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| Research Abstract |
We screened the human pancreas cDNA library using serum of theautoimmune pancreatitis with diabetes. I reported the new autoantibody which were common to autoimmune pancreatitis and fulminant type 1 diabetes mellitus by a preliminary experiment. I built the Enzyme-linked immunosorbent assay (ELISA) for detecting autoantibody against human amylase. As a result of having triedidentification of the epitope of the amylase antibody, I was able to pinpoint the part that antigenicity was high in. I try to build the ELISA having high sensitivity and specificity more now.
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