2012 Fiscal Year Final Research Report
Proteomic-based identification of renal tubular markers related to the new mechanism of urinary albumin excretion.
| Project/Area Number |
23790627
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Bunkyo Gakuin University |
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Principal Investigator |
NAKAYAMA Aki 文京学院大学, 保健医療技術学部 臨床検査学科, 助手 (00599425)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 尿中アルブミン / Tamm-Horsfall protein / エキソソーム |
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| Research Abstract |
The urinary albumin peptides metabolized in the renal tubular cells and excreted into urine, and which is considered as an in-direct tubular marker were identified by proteome analysis. The quantitative analysis of urinary Tamm-Horsfall protein showed that the significant decrease level in the patients with renal dysfunction. The proteome analysis of urinary exosomes enabled the identification of variety types of protein derived from renal epithelial cells. These results provide the basic information to predict the tubular dysfunction in renal disease condition.
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