2012 Fiscal Year Final Research Report
In vivo patch-clamp recording analysis of a pruritogen-induced itching on synaptic transmission in spinal dorsal horn
| Project/Area Number |
23790652
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
UTA Daisuke 生理学研究所, 生体情報研究系, 特任助教 (70598416)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 痒み / in vivo パッチクランプ / シナプス / 脊髄後角 / セロトニン / EPSC / 膠様質細胞 / c-fos |
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| Research Abstract |
The mechanism for the itch transmission in the spinal dorsal horn remains unclear. The present study was designed to analyze pruritic synaptic responses evoked in spinal dorsal horn neurons of rodents by using an in vivo whole-cell patch-clamp recording technique. The present main finding is that subpopulation of spinal dorsal horn neurons are responsible for pruritic cutaneous serotonin stimulation.
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