2012 Fiscal Year Final Research Report
Involvement of chemokines in abdominal pain induced by peritoneal carcinomatosis
| Project/Area Number |
23790654
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
SUZUKI Masami 独立行政法人国立がん研究センター, 研究所, 研究員 (80434182)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 疼痛 / 腹膜播種 / モルヒネ / ケモカイン / オピオイド受容体 / 脊髄後根神経節 |
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| Research Abstract |
In the present study, I developed a novel mouse model for abdominal pain due to cancerous peritonitis. Mice with peritoneal carcinomatosis exhibit hypersensitivity to mechanical stimulation and visceral pain-like behavior. In the current model, I observed a dramatic increase in the expression of substance P, but not chemokines, in the dorsal root ganglia (DRG) of mice with peritoneal dissemination, suggesting that the up-regulation of substance P may be responsible for the abdominal pain due to peritoneal carcinomatosis. Another key finding in the present study was that peritoneal dissemination decreased the expression of μ-opioid receptor (MOR) in the DRG. In relation to the down-regulation of MOR, the effect of morphine was less in tumor-bearing mice than that in inflammatory pain model mice. This newly developed model may be important for studying the pathogenesis of abdominal pain due to cancerous peritonitis.
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[Journal Article] Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and μ-opioid receptors in the spinal cord of mice.2011
Author(s)
Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashikawa M, Miyano K, Yanagihara K, Chiwaki F, Ochiya T, Suzuki T, Matoba M, Sasaki H, Uezono Y
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Journal Title
Anesthesiology
Volume: 117
Pages: 847-856
Peer Reviewed
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