An investigation of cortical representation of pain and temperature by means of dual regression technique.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23790655
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pain science
• Research Institution: National Institute of Information and Communications Technology (2013); Advanced Telecommunications Research Institute International (2011-2012)
• Principal Investigator: MANO Hiroaki 独立行政法人情報通信研究機構, 脳情報通信融合研究センター 脳情報通信融合研究室, 有期技術員 (10571581)
• Co-Investigator(Renkei-kenkyūsha): YAMAMOTO Hiroki 京都大学, 大学院人間・環境学研究科, 共生人間学専攻 認知・行動科学講座・助教 (10332727)
• Project Period (FY): 2011 – 2013
• Keywords: fMRI / pain / temperature / dual regression

Research Abstract

Simultaneous activation within a very wide array of subcortical and cortical brain structures elicited by nociceptive stimuli, called "Pain Matrix" has been conceptualized since last few decades. Those multi-regional activation have made understanding difficult due to lack of appropriate method to extract spatio-temporal information from each respective region of interest.
An exploratory analysis technique, dual regression, allows to back-reconstruct each group-level component for each of scans at the individual participant-level. It could be a solution for better understanding of cortical representation of pain and temperature.
We introduced a modified dual regression technique into our studies on thermosensory and aversive conditioning of pain, and in which we successfully obtained new findings such as the susceptiblity to experience dependent learning on human thermosensory discrimination. Fruitful experiences and paths to the future studies have been provided through the studies.

Research Products

• [Presentation] ヒト皮膚温冷感覚 (2014)
  • Author(s): 眞野博彰,吉田和子,柴田和久,シーモアベン
  • Organizer: 第36回日本疼痛学会
  • Place of Presentation: 大阪府大阪市KKRホテル大阪
  • Year and Date: 2014-06-20
• [Presentation] Perceptual learning of cutaneous thermal sensation (2013)
  • Author(s): Hiroaki Mano, Wako Yoshida, Kazuhisa Shibata, Suyi Zhang Martin Koltzenburg, Mate Lengyel, Mitsuo Kawato, Ben Seymour
  • Organizer: Society for Neuroscience 2013
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2013-11-10
• [Presentation] Dissociating specific and general learning processes during Pavlovian aversive conditioning–a parallel reinforcement learning model (2013)
  • Author(s): Suyi Zhang, Hiroaki Mano, Ganesh Gowrishankar, Trevor Robbins, Ben Seymour
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2013-11-10
• [Presentation] 皮膚温冷感覚の知覚学習 (2013)
  • Author(s): Hiroaki Mano, Wako Yoshida, Suyi Zhang, Ben Seymour
  • Organizer: 平成25年度温熱生理研究会
  • Place of Presentation: 愛知県岡崎市岡崎コンファレンスセンター
  • Year and Date: 2013-09-05
• [Presentation] Dissociating specific and general conditioned responses in Pavlovian aversive conditioning (2013)
  • Author(s): Suyi Zhang, Hiroaki Mano, Ganesh Gowrishankar, Ben Seymour
  • Organizer: Neuro2013 (第36回日本神経科学大会、第56回日本神経化学会大会、第23回日本神経回路学会大会)
  • Place of Presentation: 京都府京都市国立京都国際会館
  • Year and Date: 2013-06-22
• [Presentation] Perceptual learning of cutaneous thermal sensation (2013)
  • Author(s): Hiroaki Mano, Wako Yoshida, Kazuhisa Shibata, Suyi Zhang1 Martin Koltzenburg, Mate Lengyel, Mitsuo Kawato, Ben Seymour
  • Organizer: Neuro2013(第36回日本神経科学大会、第56回日本神経化学会大会、第23回日本神経回路学会大会)
  • Place of Presentation: 京都府京都市国立京都国際会館
  • Year and Date: 2013-06-21