2012 Fiscal Year Final Research Report
Early prediction of senile cataract based on the elucidation of mitochondrial DNA
| Project/Area Number |
23790678
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | ミトコンドリア / DNA / 水晶体上皮細胞 / シトクロム cオキシダーゼ / 白内障 / 一酸化窒素 / 酸化的ストレス / ATP / Ca^<2+>-ATPase |
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| Research Abstract |
We demonstrated that the rapidly and high production of nitric oxide (NO) caused to the mitochondrial damage in the human lens epithelial cells, and the balance in sensitivity of mitochondria and cell membrane to NO were related the mitochondrial dysfunction. In addition, the recovery time for mitochondrial function is related to exposure time to NO in human lens epithelial cells. The repetition in temporary mitochondrial dysfunction may be caused the lens opacification.
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Research Products
(5 results)
