2013 Fiscal Year Final Research Report
A historical cohort cancer incidence study of workers exposed to aromatic amines in a chemical manufacturing facility
| Project/Area Number |
23790704
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Public health/Health science
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
TOMIOKA Kimiko 奈良県立医科大学, 医学部, 助教 (20393259)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | ベンジジン / β‐ナフチルアミン / 歴史的コホート研究 / 職業性曝露 / 発がんリスク / ＳＩＲ / 産業保健 / 疫学 |
|---|
| Research Abstract |
To evaluate non-urological cancer risks associated with benzidine (BZ) and beta-naphthylamine (BNA), a historical cohort study was undertaken. 224 male workers exposed to BZ/BNA from a single factory were followed from 1953 to 2011. Standardized incidence ratio (SIR) was calculated using regional incidence rates. Association between lung cancer (LC) incidence and duration of exposure (DOE) was assessed using Cox's proportional hazards model.
Vital status follow-up was successful for 216 (96.4%). Follow-up duration averaged 44.0 (SD 10.7) years. Increased SIRs were found for all cancers (81 cases, SIR=1.72, 95%CI=1.38-2.15), LC (18 cases, 2.41, 1.43-3.81), and bladder cancer (7 cases, 5.46, 2.19-11.25). After adjustment for confounders, a marginally significant hazard ratio (HR) was observed for workers with long DOE (adjusted HR=3.02, 95%CI=0.84-10.93, p=0.091). This study confirms the high risk of LC besides bladder cancer, suggesting that BZ/BNA have the potential to cause LC.
|
