2012 Fiscal Year Final Research Report

Association between polyunsaturated fatty acids and renal function assessed by serum cystatin C in urban and rural Japanese population

Research Project

Project/Area Number	23790711
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Public health/Health science
Research Institution	Hyogo Medical University
Principal Investigator	HIGASHIYAMA Aya 兵庫医科大学, 医学部, 助教 (20533003)
Project Period (FY)	2011 – 2012
Keywords	動脈硬化 / 炎症 / エイコサペンタエン酸 / ドコサヘキサエン酸 / 腎機能 / シスタチン C
Research Abstract	Among general population in Kobe city, high-sensitivity C-reactive protein (hs-CRP) showed significant positive association with cardio-ankle vascular index (CAVI) after adjustment for age, sex and other classical cardiovascular risk factors. This result suggests that inflammation is associated with atherosclerosis which relates to renal dysfunction in general population, either. Then we investigated the association between renal function and n-3 polyunsaturated fatty acids such as EPA and DHA which are known to have anti-inflammation effects, among general population in Sasayama city. EPA and DHA showed positive relationship with glomerular filtration rate estimated by cystatin C. Thus fish intake could prevent renal dysfunction in general population.