Elevated Serum N-acetyl-s-D-Glucosaminidase Activity is a Predictor of 28-Year Mortality in a Population of Community-dwelling Japanese

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790713
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Public health/Health science
• Research Institution: Kurume University
• Principal Investigator: YOSHIKAWA Kuniko 久留米大学, 医学部, 助教 (60569391)
• Project Period (FY): 2011 – 2012
• Keywords: 健康診断 / 疫学 / アセチルグルコサミニダーゼ / 死亡率 / 前向き研究

Research Abstract

Elevated serum N-acetyl-s-D-Glucosaminidase (NAG) activity is related to various cardiovascular risk factors and is a predictor of incident hypertension. Urinary but not serum NAG activity was an important prognostic marker in renal diseases. We measured serum NAG activities in 1,080 apparently healthy subjects (aged over 20 years) in 1982. Importantly, we reported 17 years ago that high serum NAG activity was a predictor of future development of hypertension in a general population. We hypothesized that elevated serum NAG activity would be a predictor of cerebro-cardiovascular death in community-based cohort study. Accordingly, we examined whether the serum NAG activity would predict 28-year cerebro-cardiovascular and all-cause deaths in the same population. The hazard ratio of all-cause death in the highest quartile of serum NAG (?14.0 IU/L) vs. the lowest quartile after adjustment for confounding factors was 1.35 (95% CI,1.02-1.83). On the other hand, no significant associatins were found between NAG activities and cardiovascular mortality. In conclusion, the present study suggests that the serum NAG activity is an independent predictor of all-cause mortality in a general population.

Research Products

• [Journal Article] New computer model for prediction of individual 10-year mortality on the basis of conventionalatherosclerotic risk factors. (2013)
  • Author(s): Ogata K, MiyamotoT, Adachi H, Hirai Y, Enomoto M, Fukami A, Yokoi K, Kasahara A, Tsukagawa E, Yoshimura A, Obuchi A, Nakamura S, Imaizumi T.
  • Journal Title: Atherosclerosis. Volume: 227 Pages: 159-164
  • DOI: DOI:10.1016/j.atherosclerosis.2012.12.023.
  • Peer Reviewed
• [Journal Article] High serum N-acetyl- β -d-glucosaminidase activity is predictor of 28-year mortality in a population of community-dwelling Japanease ? the Tanushimaru study. (2013)
  • Author(s): Yoshikawa K, Adachi H, Hirai Y, Enomoto M, Fukami A, Ogata K, Tsukagawa E, Kasahara A, Yokoi K, Okina N, Obuchi A, Yoshimura A, Nakamura S, Imaizumi T.
  • Journal Title: J Am Geriatr Soc. Volume: 61(3) Pages: 467-468
  • DOI: DOI:10.1111/jgs.12083.
  • Peer Reviewed
• [Journal Article] High level of plasma remnant-like particle cholesterol may predispose to development of hypertention in normotensive subjects. (2013)
  • Author(s): Kasahara A, Adachi H, Hirai Y, Enomoto M, Fukami A, Yoshikawa K, Esaki E, Yokoi K, Ogata K, Tsukagawa E, Obuchi A, Yoshimura A, Nakamura S, Imaizumi T.
  • Journal Title: Am J Hypertens. Volume: 26(6) Pages: 793-798
  • DOI: DOI:10.1093/ajh/hpt011
  • Peer Reviewed
• [Journal Article] Serum hepatocyte growth factor and cancer mortality in an apparently healthy Japanese population. (2012)
  • Author(s): Otsuka M, Adachi H, Jacobs DR Jr, Hirai Y, Enomoto M, Fukami A, Kumagae S, Nanjo Y, Yoshikawa K, Esaki E, Kumagai E, Yokoi K, Ogata K, Tsukagawa E, Kasahara A, Ohbu K, Imaizumi T.
  • Journal Title: J Epidemiol. Volume: 22(5) Pages: 395-401
  • Peer Reviewed
• [Journal Article] Plasma aldosterone levels and development of insulin resistance: prospective study in a general population. (2011)
  • Author(s): Kumagai E, Adachi H, Jacobs DR Jr, Hirai Y, Enomoto M, Fukami A, Otsuka M, Kumagae S, Nanjo Y, Yoshikawa K, Esaki E, Yokoi K, Ogata K, Kasahara A, Tsukagawa E, Ohbu-Murayama K, Imaizumi T.
  • Journal Title: Hypertension. Volume: 58(6) Pages: 1043-1048
  • DOI: DOI:10.1161/HYPERTENSIONAHA.111.180521.
  • Peer Reviewed
• [Journal Article] LDL-C/HDL-C ratio predicts carotid intima-media thickness progression better than HDL-C or LDL-C alone (2011)
  • Author(s): Enomoto M, Adachi H, Hirai Y, Fukami A, Satoh A, Otsuka M, Kumagae S, Nanjo Y, Yoshikawa K, Esaki E, Kumagai E, Ogata K, Kasahara A, Tsukagawa E, Yokoi K, Ohbu-Murayama K, Imaizumi T.
  • Journal Title: J Lipids. 2011 Pages: 549137
  • DOI: DOI:10.1155/2011/549137.
  • Peer Reviewed
• [Presentation] Elevated Serum N-acetyl-s-D-Glucosaminidase Activity is a Predictor of 28-Year Mortality in a Population of Community-dwelling Japanese-The Tanushimaru Study ? (2011)
  • Author(s): 吉川 邦子
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜市
  • Year and Date: 20110803-0804