2012 Fiscal Year Final Research Report
Alzheimer disease caused by vascular senescence and the mechanisms of prevention from it
| Project/Area Number |
23790737
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OTA Hidetaka 東京大学, 医学部附属病院, 助教 (20431869)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 血管老化 / アルツハイマー型認知症 / Sirt1 |
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| Research Abstract |
We found that treatment with testosterone ameliorated cognitive function and inhibited senescence of hippocampal vascular endothelial cells of SAMP8. Notably, SAMP8 showed enhancement of oxidative stress in the hippocampus. We observed that an NAD+-dependent deacetylase, SIRT1, played an important role in the protective effect of testosterone against oxidative stress-induced endothelial senescence.
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