2013 Fiscal Year Final Research Report
Central regulation mechanisms of brain endocannabinoid-induced inhibitory effects on central activation of sympatho-adrenomedullary outflow
| Project/Area Number |
23790744
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳内大麻 / エンドカンナビノイド / 2-アラキドノイルグリセロール / カンナビノイドCB受容体 / 中枢性交感神経ー副腎髄質系 / グルタミン酸神経系 / 視床下部室傍核（PVN） / ストレス |
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| Research Abstract |
We examined central regulation mechanisms of sympatho-adrenomedullary (SA) outflow, which plays an important role in pathophysiological responses to stressors, regarding brain 2-arachidonoylglycerol (2-AG), an endogenous ligand for cannabinoid receptors (endocannabinoid, eCB), and the hypothalamic paraventricular nucleus (PVN), a regulatory center of the outflow. The results from the present studies suggest that (1) brain 2-AG can be metabolized to prostaglandin E2 (PGE2) glycerol ester, thereby activating the SA outflow as a precursor of PGE2, and that (2) brain eCB can be suppressively involved in the central SA outflow in the PVN by inhibiting glutamate release from the glutamatergic nerves innervating the PVN. These findings indicate a possibility that drugs activating brain eCB signals may be beneficial for clinical application to "stress-related disorders", such as hypertension, developed by high levels of stress-induced excess activation of the SA outflow.
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Research Products
(24 results)
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[Journal Article] Possible involvement of brain pro staglandin E_2 and prostanoid EP_3 recepto rs in prostaglandin E_2 glycerol ester-in duced activation of central sympathetic outflow in the rat2014
Author(s)
Shimizu T,Tanaka K,Nakamura K,Tani uchi K,Yawata T,Higashi Y,Ueba T,Di mitriadis F,Shimizu S,Yokotani K,Saito M
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Journal Title
Neuropharmacology
Volume: 82
Pages: 19-27
DOI
Peer Reviewed
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[Journal Article] Brain RVD-h aemopressin,a haemoglobin-derived pept ide,inhibits bombesin-induced central activation of adrenomedullary outflow i n the rat2014
Author(s)
Tanaka K,Shimizu T,Yanagita T,Nem oto T,Nakamura K,Taniuchi K,Dimitria dis F,Yokotani K,Saito M
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Journal Title
Br. J. Pharmacol.
Volume: 171
Pages: 202-213
DOI
Peer Reviewed
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